Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

Jonathan H. Wardman; Ivone Gomes; Erin N. Bobeck; Jennifer A. Stockert; Abhijeet Kapoor; Paola Bisignano; Achla Gupta; Mihaly Mezei; Sanjai Kumar; Marta Filizola; Lakshmi A. Devi

doi:10.1126/scisignal.aac8035

Research ArticlePharmacology

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

Jonathan H. Wardman¹,*,†,
Ivone Gomes¹,*,
Erin N. Bobeck¹,*,
Jennifer A. Stockert¹,
Abhijeet Kapoor²,
Paola Bisignano²,
Achla Gupta¹,
Mihaly Mezei²,
Sanjai Kumar³,
Marta Filizola², and
Lakshmi A. Devi¹,‡

¹Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
²Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
³Department of Chemistry and Biochemistry, Queens College, Flushing, NY 11367, USA.

↵‡Corresponding author. Email: lakshmi.devi{at}mssm.edu

↵* These authors contributed equally to this work.
↵† Present address: Department of Neurology, Rigshospitalet, 1429 Copenhagen, Denmark.

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Science Signaling 31 May 2016:
Vol. 9, Issue 430, pp. ra55
DOI: 10.1126/scisignal.aac8035

Jonathan H. Wardman

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Ivone Gomes

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Erin N. Bobeck

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Jennifer A. Stockert

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Abhijeet Kapoor

Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Paola Bisignano

Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Achla Gupta

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Mihaly Mezei

Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Sanjai Kumar

Department of Chemistry and Biochemistry, Queens College, Flushing, NY 11367, USA.

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Marta Filizola

Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Lakshmi A. Devi

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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For correspondence: lakshmi.devi@mssm.edu

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