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Papers of note in Science Translational Medicine

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Science Signaling  14 Jun 2016:
Vol. 9, Issue 432, pp. ec142
DOI: 10.1126/scisignal.aag3191


α-Synuclein disrupts the mitochondrial protein import business

The Parkinson’s disease–associated protein α-synuclein binds to the mitochondrial protein import receptor TOM20, which causes downstream impairment of mitochondrial function.

R. Di Maio, P. J. Barrett, E. K. Hoffman, C. W. Barrett, A. Zharikov, A. Borah, X. Hu, J. McCoy, C. T. Chu, E. A. Burton, T. G. Hastings, J. T. Greenamyre, α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease. Sci. Transl. Med. 8, 342ra78 (2016). [Abstract]


Knocking down adhesion, knocking out inflammation

Nanoparticles deliver siRNA for multigene silencing of endothelial cell adhesion molecules, which dampens leukocyte recruitment in atherosclerosis and myocardial infarction in mice.

H. B. Sager, P. Dutta, J. E. Dahlman, M. Hulsmans, G. Courties, Y. Sun, T. Heidt, C. Vinegoni, A. Borodovsky, K. Fitzgerald, G. R. Wojtkiewicz, Y. Iwamoto, B. Tricot, O. F. Khan, K. J. Kauffman, Y. Xing, T. E. Shaw, P. Libby, R. Langer, R. Weissleder, F. K. Swirski, D. G. Anderson, M. Nahrendorf, RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci. Transl. Med. 8, 342ra80 (2016). [Abstract]

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