MUCOSAL IMMUNOLOGY
Location matters for immunosuppression
The microenvironment shapes the phenotype and function of suppressive T lymphocyte populations in the gut.
T. Sujino, M. London, D. P. H. van Konijnenburg, T. Rendon, T. Buch, H. M. Silva, J. J. Lafaille, B. S. Reis, D. Mucida, Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science 352, 1581–1586 (2016). [Abstract]
M. Colonna, L. Cervantes-Barragan, Converting to adapt. Science 352, 1515–1516 (2016). [Abstract]
Mounting the intestinal barricades
Innate immune signaling and inflammasome activation trigger mucus release and goblet cell expulsion from the intestinal crypts.
G. M. H. Birchenough, E. E. L. Nyström, M. E. V. Johansson, G. C. Hansson, A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535–1542 (2016). [Abstract]
STRUCTURAL BIOLOGY
Holding kinases at the ready
The Hsp90 chaperone system modulates and stabilizes kinases via a functionally relevant, unfolded open state.
K. A. Verba, R. Y.-R. Wang, A. Arakawa, Y. Liu, M. Shirouzu, S. Yokoyama, D. A. Agard, Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Science 352, 1542–1547 (2016). [Abstract]
