FocusCancer Immunology

Tumor microenvironment on the move and the Aselli connection

See allHide authors and affiliations

Science Signaling  28 Jun 2016:
Vol. 9, Issue 434, pp. fs13
DOI: 10.1126/scisignal.aag2279


The tumor microenvironment is involved in many activities that promote tumor cell growth, local spreading, and metastasis. In this issue of Science Signaling, Jung et al. found that lymphangiogenesis may result from the cooperation of two molecules, sphingosine-1-phosphate (S1P) and lipocalin 2 (LCN2), produced by tumor cells and macrophages, respectively. The new S1P-LCN2 axis stresses the importance of innate immunity in remodeling the tumor microenvironment and in lymphangiogenesis.

View Full Text

Stay Connected to Science Signaling