STRUCTURAL BIOLOGY
Stargazin and the AMPA receptor
Neuronal AMPA receptor auxiliary subunits control synaptic function through variable interaction stoichiometry and electrostatics.
E. C. Twomey, M. V. Yelshanskaya, R. A. Grassucci, J. Frank, A. I. Sobolevsky, Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy. Science 353, 83–86 (2016). [Abstract]
POSTTRANSLATIONAL MODIFICATIONS
Mapping ADP-ribosylation by PARPs
An NAD+ analog–sensitive poly(ADP-ribose) polymerase reveals key proteins and genomic loci ADP-ribosylated by PARPs for gene regulation.
B. A. Gibson, Y. Zhang, H. Jiang, K. M. Hussey, J. H. Shrimp, H. Lin, F. Schwede, Y. Yu, W. L. Kraus, Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 353, 45–50 (2016). [Abstract]
PROTEOSTASIS
Making and maintaining a healthy proteome
A review describes how the proteostasis network within cells helps to make and maintain the proteome.
D. Balchin, M. Hayer-Hartl, F. U. Hartl, In vivo aspects of protein folding and quality control. Science 353, aac4354 (2016). [Abstract]
CENTROSOMES
Kicking out an unwanted centrosome
How and why female gametes eliminate their centrosomes during oogenesis is elucidated.
A. Pimenta-Marques, I. Bento, C. A. M. Lopes, P. Duarte, S. C. Jana, M. Bettencourt-Dias, A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster. Science 353, aaf4866 (2016). [Abstract]
RETINAL REPAIR
MANF enough for tissue repair
A conserved immune modulatory mechanism promotes retinal repair in Drosophila and mouse.
J. Neves, J. Zhu, P. Sousa-Victor, M. Konjikusic, R. Riley, S. Chew, Y. Qi, H. Jasper, D. A. Lamba, Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science 353, aaf3646 (2016). [Abstract]
E. G. Cameron, J. L. Goldberg, Promoting CNS repair. Science 353, 30–31 (2016). [Abstract]
