Research ResourceBiochemistry

Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway

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Science Signaling  12 Jul 2016:
Vol. 9, Issue 436, pp. rs6
DOI: 10.1126/scisignal.aaf0891

Adaptors are the conductors in the signaling symphony

Just as there are rate-limiting enzymes in biochemical process, there are rate-limiting steps in cell signaling networks. These rate-limiting proteins direct the signal through specific molecular cascades to dictate the response. Shi et al. sought to identify the proteins in the epidermal growth factor receptor (EGFR) signaling network that serve as the conductors or directors of the EGF signal. They found that the abundance of most core pathway proteins was very similar between cells and rather that the very low abundance of the adaptor proteins made them rate-limiting for EGFR-MAPK pathway signaling in normal and malignant cells. The findings suggest that adaptor proteins serve as the directors of the signaling script.

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