Contents

Contents

• Research Articles

  • Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

    By Seungil Kim, Devin M. Barry, Xian-Yu Liu, Shijin Yin, Admire Munanairi, Qing-Tao Meng, Wei Cheng, Ping Mo, Li Wan, Shen-Bin Liu, Kasun Ratnayake, Zhong-Qiu Zhao, Narasimhan Gautam, Jie Zheng, W. K. Ajith Karunarathne, Zhou-Feng Chen

    Science Signaling19 Jul 2016 : ra71 Full AccessRestricted Access

    Sensory neurons use a pair of TRP channels to respond to some itch-inducing chemicals.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

    By Emma J. Gordon, Daisuke Fukuhara, Simone Weström, Narendra Padhan, Elisabet O. Sjöström, Laurens van Meeteren, Liqun He, Fabrizio Orsenigo, Elisabetta Dejana, Katie Bentley, Anne Spurkland, Lena Claesson-Welsh

    Science Signaling19 Jul 2016 : ra72 Full AccessRestricted Access

    The adaptor protein TSAd helps endothelial cells disconnect so that they can migrate and form new blood vessels.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

    By Jonathan M. Weiss, Wei Chen, Melanie S. Nyuydzefe, Alissa Trzeciak, Ryan Flynn, James R. Tonra, Suzana Marusic, Bruce R. Blazar, Samuel D. Waksal, Alexandra Zanin-Zhorov

    Science Signaling19 Jul 2016 : ra73 Full AccessRestricted Access

    Inhibition of the kinase ROCK2 specifically prevents a subset of T cells from contributing to autoimmunity.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Editors' Choice

  • Pore-forming death signal

    By John F. Foley, Nancy R. Gough

    Science Signaling19 Jul 2016 : ec163 Full AccessRestricted Access

    The N-terminal domain of gasdermin D oligomerizes and forms plasma membrane pores to kill cells by pyroptosis.

    • Abstract

  • Family planning for worms

    By Annalisa M. VanHook

    Science Signaling19 Jul 2016 : ec164 Full AccessRestricted Access

    Dietary nutrients and developmental timing mechanisms control germline development in nematodes.

    • Abstract

  • Cancer reactivated by collagen

    By Leslie K. Ferrarelli

    Science Signaling19 Jul 2016 : ec165 Full AccessRestricted Access

    The tetraspanin TM4SF1 mediates type I collagen–triggered reactivation of dormant breast cancer cells.

    • Abstract

  • Paper of note in Science Translational Medicine

    By Leslie K. Ferrarelli

    Science Signaling19 Jul 2016 : ec166 Full AccessRestricted Access

    This week’s article describes how gene therapy may be a neuroprotective strategy for spinocerebellar ataxia.

    • Abstract

  • Papers of note in Science

    By Annalisa M. VanHook

    Science Signaling19 Jul 2016 : ec167 Full AccessRestricted Access

    This week’s articles highlight a regulatory interaction between organelles, a mechanism that controls neural stem cell quiescence, epigenetic regulation of neural activity, and the structural basis of glutamatergic signaling.

    • Abstract

  • Shutting down oxygen use

    By Nancy R. Gough

    Science Signaling19 Jul 2016 : ec168 Full AccessRestricted Access

    Cancer cells can shut down nonmitochondrial oxygen use with PTP1B to survive hypoxic conditions.

    • Abstract