Contents
19 July 2016
Vol 9, Issue 437
Vol 9, Issue 437
Contents
Research Articles
- Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations
Sensory neurons use a pair of TRP channels to respond to some itch-inducing chemicals.
- The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation
The adaptor protein TSAd helps endothelial cells disconnect so that they can migrate and form new blood vessels.
- ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings
Inhibition of the kinase ROCK2 specifically prevents a subset of T cells from contributing to autoimmunity.
Editors' Choice
- Pore-forming death signal
The N-terminal domain of gasdermin D oligomerizes and forms plasma membrane pores to kill cells by pyroptosis.
- Family planning for worms
Dietary nutrients and developmental timing mechanisms control germline development in nematodes.
- Cancer reactivated by collagen
The tetraspanin TM4SF1 mediates type I collagen–triggered reactivation of dormant breast cancer cells.
- Paper of note in Science Translational Medicine
This week’s article describes how gene therapy may be a neuroprotective strategy for spinocerebellar ataxia.
- Papers of note in Science
This week’s articles highlight a regulatory interaction between organelles, a mechanism that controls neural stem cell quiescence, epigenetic regulation of neural activity, and the structural basis of glutamatergic signaling.
- Shutting down oxygen use
Cancer cells can shut down nonmitochondrial oxygen use with PTP1B to survive hypoxic conditions.
About The Cover
Online Cover This week features a Research Article that describes how the adaptor protein TSAd helps endothelial cells uncouple so that they can form new blood vessels. The image shows blood vessels (denoted by green and red) surrounding trachea. [Image: Emma Gordon/Uppsala University, Sweden]