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vol. 9 no. 437 ra71
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History:
- Received December 17, 2015
- Accepted July 1, 2016
- .
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Copyright © 2016, American Association for the Advancement of Science
Research ArticleSensory Perception
Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations
- Seungil Kim1,2,*,†,
- Devin M. Barry1,2,*,
- Xian-Yu Liu1,2,*,
- Shijin Yin1,2,
- Admire Munanairi1,2,
- Qing-Tao Meng1,3,
- Wei Cheng4,
- Ping Mo1,5,
- Li Wan1,‡,
- Shen-Bin Liu1,2,
- Kasun Ratnayake6,
- Zhong-Qiu Zhao1,2,
- Narasimhan Gautam2,7,
- Jie Zheng8,
- W. K. Ajith Karunarathne6, and
- Zhou-Feng Chen1,2,9,10,§
- 1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 3Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
- 4Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, P.R. China.
- 5Department of Anesthesiology, Nanhai Hospital of Southern Medical University, Foshan 528000, P.R. China.
- 6Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.
- 7Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 8Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616, USA.
- 9Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 10Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- ↵§Corresponding author. Email: chenz{at}wustl.edu
↵* These authors contributed equally to this work.
↵† Present address: Department of Cell and Tissue Biology, Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
↵‡ Present address: Department of Anesthesiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, P.R. China.
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Science Signaling 19 Jul 2016:
Vol. 9, Issue 437, pp. ra71
DOI: 10.1126/scisignal.aaf1047
Vol. 9, Issue 437, pp. ra71
DOI: 10.1126/scisignal.aaf1047
Seungil Kim
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Devin M. Barry
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xian-Yu Liu
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shijin Yin
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Admire Munanairi
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Qing-Tao Meng
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
3Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Wei Cheng
4Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, P.R. China.
Ping Mo
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
5Department of Anesthesiology, Nanhai Hospital of Southern Medical University, Foshan 528000, P.R. China.
Li Wan
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shen-Bin Liu
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kasun Ratnayake
6Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.
Zhong-Qiu Zhao
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Narasimhan Gautam
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
7Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jie Zheng
8Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616, USA.
W. K. Ajith Karunarathne
6Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.
Zhou-Feng Chen
1Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
9Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
10Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
