Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

Seungil Kim; Devin M. Barry; Xian-Yu Liu; Shijin Yin; Admire Munanairi; Qing-Tao Meng; Wei Cheng; Ping Mo; Li Wan; Shen-Bin Liu; Kasun Ratnayake; Zhong-Qiu Zhao; Narasimhan Gautam; Jie Zheng; W. K. Ajith Karunarathne; Zhou-Feng Chen

doi:10.1126/scisignal.aaf1047

Research ArticleSensory Perception

Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

Seungil Kim¹,²,*,†,
Devin M. Barry¹,²,*,
Xian-Yu Liu¹,²,*,
Shijin Yin¹,²,
Admire Munanairi¹,²,
Qing-Tao Meng¹,³,
Wei Cheng⁴,
Ping Mo¹,⁵,
Li Wan¹,‡,
Shen-Bin Liu¹,²,
Kasun Ratnayake⁶,
Zhong-Qiu Zhao¹,²,
Narasimhan Gautam²,⁷,
Jie Zheng⁸,
W. K. Ajith Karunarathne⁶, and
Zhou-Feng Chen¹,²,⁹,¹⁰,§

¹Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
²Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
³Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
⁴Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, P.R. China.
⁵Department of Anesthesiology, Nanhai Hospital of Southern Medical University, Foshan 528000, P.R. China.
⁶Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.
⁷Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
⁸Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616, USA.
⁹Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
¹⁰Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

↵§Corresponding author. Email: chenz{at}wustl.edu

↵* These authors contributed equally to this work.
↵† Present address: Department of Cell and Tissue Biology, Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
↵‡ Present address: Department of Anesthesiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, P.R. China.

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Science Signaling 19 Jul 2016:
Vol. 9, Issue 437, pp. ra71
DOI: 10.1126/scisignal.aaf1047

Seungil Kim

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Devin M. Barry

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Xian-Yu Liu

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Shijin Yin

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Admire Munanairi

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Qing-Tao Meng

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

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Wei Cheng

Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, P.R. China.

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Ping Mo

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Nanhai Hospital of Southern Medical University, Foshan 528000, P.R. China.

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Li Wan

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Shen-Bin Liu

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Kasun Ratnayake

Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.

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Zhong-Qiu Zhao

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Narasimhan Gautam

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Jie Zheng

Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616, USA.

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W. K. Ajith Karunarathne

Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.

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Zhou-Feng Chen

Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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For correspondence: chenz@wustl.edu

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Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

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