Contents
02 August 2016
Vol 9, Issue 439
Vol 9, Issue 439
Contents
Research Articles
- Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter
Evaluation of a patient with peripheral motor weakness reveals a key role for phosphorylation-dependent regulation of the transporter KCC3 in the peripheral nervous system.
- Small heterodimer partner SHP mediates liver X receptor (LXR)–dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes
The transcriptional regulator SHP promotes SUMOylation of the LXR transcriptional factors specifically in astrocytes to limit inflammatory signaling.
Research Resource
- Multiplex matrix network analysis of protein complexes in the human TCR signalosome
A multiplex antibody-mediated capture technique reveals patient-specific protein complexes.
Podcast
- Science Signaling Podcast for 2 August 2016: Patient-specific protein complexes
A technique for identifying patient-specific protein complexes reveals altered signaling in T cells from patients with the autoimmune disease alopecia areata.
Editors' Choice
- Astrocytes donate mitochondria
Astrocytes release mitochondria that help neurons survive stroke.
- Targeting AURKA to drug the undruggable
Drugs that prevent aurora kinase A from interacting with the transcription factor MYC may treat p53-mutant liver cancer.
- TNF drives thymocyte development
The survival and development of single-positive thymocytes in the thymus requires activation of NF-κB signaling by the cytokine TNF.
- Papers of note in Science
This week’s articles are about virulence of the plague bacterium, resistance to parasite attack, a transcription factor that keeps plants from flowering prematurely, an epigenetic link between in utero nutrition and growth, and a synthetic biological system for tracking a cell’s history.
- Paper of note in Science Translational Medicine
This week’s article describes how exposure to near-infrared laser light might be therapeutic for patients with thrombocytopenia.
About The Cover
Online Cover This week features a Research Article that describes how evaluation of a patient with peripheral motor weakness revealed a key role for phosphorylation-dependent regulation of the transporter KCC3 in the peripheral nervous system. The image shows the aberrant double-myelin rings, indicative of neuropathology, that occurred in mice engineered to have the same mutation as found in the patient. [Image: Bianca Flores, Neuroscience Graduate Program, Vanderbilt University, Nashville, TN]