Research ArticleBiochemistry

Small heterodimer partner SHP mediates liver X receptor (LXR)–dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes

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Science Signaling  02 Aug 2016:
Vol. 9, Issue 439, pp. ra78
DOI: 10.1126/scisignal.aaf4850

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SHP delivers SUMO to suppress inflammation

Inflammation contributes to various neurodegenerative diseases and occurs in response to brain injury. LXR transcriptional repressors suppress the expression of inflammatory genes. Lee et al. found that an orphan nuclear receptor called SHP (also known as NR0B2) facilitated the attachment of SUMO to LXRs specifically in astrocytes, either by acting as a bridge between LXRα and its SUMO-conjugating enzyme HDAC4 or by preventing the degradation of PIAS1, the SUMO-conjugating enzyme for LXRβ. The findings present opportunities for future drug development to limit neuroinflammation.

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