Papers of note in Science

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Science Signaling  09 Aug 2016:
Vol. 9, Issue 440, pp. ec183
DOI: 10.1126/scisignal.aai7398


Insights into proteasome inhibition

High-resolution structures of human 20S proteasomes reveal chemical principles for next-generation drug design.

J. Schrader, F. Henneberg, R. A. Mata, K. Tittmann, T. R. Schneider, H. Stark, G. Bourenkov, A. Chari, The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353, 594–598 (2016). [Abstract]


Axonal pathology and necroptosis in ALS

Inflammatory and cell death mechanisms underlie axonal pathology in amyotrophic lateral sclerosis.

Y. Ito, D. Ofengeim, A. Najafov, S. Das, S. Saberi, Y. Li, J. Hitomi, H. Zhu, H. Chen, L. Mayo, J. Geng, P. Amin, J. Park DeWitt, A. K. Mookhtiar, M. Florez, A. T. Ouchida, J.-b. Fan, M. Pasparakis, M. A. Kelliher, J. Ravits, J. Yuan, RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 353, 603–608 (2016).[Abstract]


Searching for the Sun

Sun-tracking when young, east-facing when mature, warmer sunflowers attract more pollinators.

H. S. Atamian, N. M. Creux, E. A. Brown, A. G. Garner, B. K. Blackman, S. L. Harmer, Circadian regulation of sunflower heliotropism, floral orientation, and pollinator visits. Science 353, 587–590 (2016).[Abstract]

W. R. Briggs, How do sunflowers follow the Sun—and to what end? Science 353, 541–542 (2016). [Abstract]

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