Research ResourceNeuroscience

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome

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Science Signaling  09 Aug 2016:
Vol. 9, Issue 440, pp. rs8
DOI: 10.1126/scisignal.aaf6716

Defining the PSD risk for psychiatric disease

Li et al. stimulated mouse hippocampi to induce long-term potentiation (LTP; a form of synaptic plasticity), isolated the CA1 region, and then performed both a proteomic analysis and a protein-protein interaction analysis of the postsynaptic density (PSD), a cellular compartment containing more than 1500 proteins. Bioinformatics analysis of this data set indicated that risk factors associated with autism spectrum disorder and schizophrenia were contained within the phosphoproteins that were differentially regulated by the induction of LTP, such that excluding these proteins from the analysis completely removed any association with the risk of having either of these two psychiatric diseases. The data provided, along with this medical association of disease risk, should guide researchers and clinicians toward a better understanding of both the molecular changes that enable learning and memory as well as the complex neurological diseases involving proteins that are part of the PSD.