Contents
Vol 9, Issue 441
Contents
Research Articles
- H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea
Suppressing hydrogen sulfide production in the carotid body may prevent the hypertension associated with sleep apnea.
- The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus
The second messenger c-di-AMP binds to and inhibits a component of a transporter that helps bacterial cells adapt to osmotic stress.
- Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
PI3Kβ mediates synergistic signaling upon costimulation of GPCRs and receptor tyrosine kinases in immune cells.
Editors' Choice
- Another reason to eat more fiber
Metabolites produced by fiber-fermenting gut bacteria help B cells produce antibodies.
- Limiting T cell histidine phosphorylation
Phosphoglycerate mutase 5 (PGAM5) limits T cell activation by dephosphorylating the histidine kinase NDPK-B.
- The fat of the (cancer) matter
Adipocytes secrete molecules that promote pancreatic and ovarian tumor progression.
- Paper of note in Science Translational Medicine
This week’s article describes a less toxic approach to deplete stem cells from bone marrow to enable transplantation.
- Papers of note in Science
This week’s articles offer insights into the gating mechanism of a voltage-sensitive potassium channel and how sleep deprivation and circadian rhythms combine to affect brain activity.
- New connections: Regulating transporters
Bacteria, plants, and animals rely on proper regulation of transporters for health and survival in changing conditions.
About The Cover

Online Cover This week features a Research Article that demonstrates that the cyclic dinucleotide c-di-AMP prevents inappropriate activity of a transporter that helps bacterial cells adapt to osmotic stress. The image illustrates c-di-AMP binding to a component of the transporter OpuC. The blue and green lines represent solute transport through this multiprotein complex. [Image: Christopher Schuster, Imperial College London]