Contents

Contents

• Research Articles

  • H₂S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea

    By Guoxiang Yuan, Ying-Jie Peng, Shakil A. Khan, Jayasri Nanduri, Amritha Singh, Chirag Vasavda, Gregg L. Semenza, Ganesh K. Kumar, Solomon H. Snyder, Nanduri R. Prabhakar

    Science Signaling16 Aug 2016 : ra80 Full AccessRestricted Access

    Suppressing hydrogen sulfide production in the carotid body may prevent the hypertension associated with sleep apnea.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus

    By Christopher F. Schuster, Lauren E. Bellows, Tommaso Tosi, Ivan Campeotto, Rebecca M. Corrigan, Paul Freemont, Angelika Gründling

    Science Signaling16 Aug 2016 : ra81 Full AccessRestricted Access

    The second messenger c-di-AMP binds to and inhibits a component of a transporter that helps bacterial cells adapt to osmotic stress.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

    By Daniel M. Houslay, Karen E. Anderson, Tamara Chessa, Suhasini Kulkarni, Ralph Fritsch, Julian Downward, Jonathan M. Backer, Len R. Stephens, Phillip T. Hawkins

    Science Signaling16 Aug 2016 : ra82 Full AccessRestricted Access

    PI3Kβ mediates synergistic signaling upon costimulation of GPCRs and receptor tyrosine kinases in immune cells.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Editors' Choice

  • Another reason to eat more fiber

    By Annalisa M. VanHook

    Science Signaling16 Aug 2016 : ec184 Full AccessRestricted Access

    Metabolites produced by fiber-fermenting gut bacteria help B cells produce antibodies.

    • Abstract

  • Limiting T cell histidine phosphorylation

    By Nancy R. Gough

    Science Signaling16 Aug 2016 : ec185 Full AccessRestricted Access

    Phosphoglycerate mutase 5 (PGAM5) limits T cell activation by dephosphorylating the histidine kinase NDPK-B.

    • Abstract

  • The fat of the (cancer) matter

    By Leslie K. Ferrarelli

    Science Signaling16 Aug 2016 : ec186 Full AccessRestricted Access

    Adipocytes secrete molecules that promote pancreatic and ovarian tumor progression.

    • Abstract

  • Paper of note in Science Translational Medicine

    By Leslie K. Ferrarelli

    Science Signaling16 Aug 2016 : ec187 Full AccessRestricted Access

    This week’s article describes a less toxic approach to deplete stem cells from bone marrow to enable transplantation.

    • Abstract

  • Papers of note in Science

    By Annalisa M. VanHook

    Science Signaling16 Aug 2016 : ec188 Full AccessRestricted Access

    This week’s articles offer insights into the gating mechanism of a voltage-sensitive potassium channel and how sleep deprivation and circadian rhythms combine to affect brain activity.

    • Abstract

  • New connections: Regulating transporters

    By Nancy R. Gough

    Science Signaling16 Aug 2016 : ec189 Full AccessRestricted Access

    Bacteria, plants, and animals rely on proper regulation of transporters for health and survival in changing conditions.

    • Abstract