Contents
23 August 2016
Vol 9, Issue 442
Vol 9, Issue 442
Contents
Research Articles
- Dynamic DNA methylation regulates neuronal intrinsic membrane excitability
The intrinsic excitability of cortical pyramidal neurons is set by dynamic DNA cytosine methylation.
- Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program
In tumors with mutant p53, both Ras and TGF-β promote metastatic disease by stimulating ΔNp63 activity.
- Negative regulation of NF-κB p65 activity by serine 536 phosphorylation
The kinase IKK fine-tunes inflammation by both activating and inhibiting signaling by the p65 subunit of NF-κB.
Editors' Choice
- A signal to warm up to
IL-33 and its receptor ST2 induce a postnatal switch from coupled to uncoupled respiration in beige and brown adipocytes.
- Prepping the premetastatic niche
Targeting TLR3 might suppress metastatic growth in the lung.
- A useful off-target effect
A drug developed to inhibit receptor tyrosine kinases also binds to an E3 ubiquitin ligase to promote the degradation of β-catenin.
- The mechanics of the first heartbeat
Mechanical, not electrical, signals coordinate the first heartbeats in the developing embryo.
- Papers of note in Science
This week’s articles describe the precise structures of the plant hormones gibberellin and jasmonic acid and present an atlas of maize development that integrates transcriptomic, proteomic, and phosphoproteomic data.
- Papers of note in Science Translational Medicine
This week’s articles describe a way to promote liver regeneration and a safer therapeutic option for congenital adrenal hyperplasia.
About The Cover
Online Cover This week features a Research Article showing that dynamic DNA cytosine methylation controls the abundance of a potassium channel to alter the intrinsic excitability of cortical neurons. [Image: kirstypargeter/iStockphoto.com]