REGENERATIVE MEDICINE
Drug-induced regeneration
Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor of Hippo kinase MST1/2 provides a therapeutic option for tissue injury and repair.
F. Fan, Z. He, L.-L. Kong, Q. Chen, Q. Yuan, S. Zhang, J. Ye, H. Liu, X. Sun, J. Geng, L. Yuan, L. Hong, C. Xiao, W. Zhang, X. Sun, Y. Li, P. Wang, L. Huang, X. Wu, Z. Ji, Q. Wu, N.-S. Xia, N. S. Gray, L. Chen, C.-H. Yun, X. Deng, D. Zhou, Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci. Transl. Med. 8, 352ra108 (2016). [Abstract]
METABOLISM
A kinder, gentler steroid
Corticosterone is as effective as cortisol for ACTH suppression but lacks metabolic adverse effects.
M. Nixon, S. D. Mackenzie, A. I. Taylor, N. Z. M. Homer, D. E. Livingstone, R. Mouras, R. A. Morgan, D. J. Mole, R. H. Stimson, R. M. Reynolds, A. P. D. Elfick, R. Andrew, B. R. Walker, ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy. Sci. Transl. Med. 8, 352ra109 (2016). [Abstract]
