Research ArticleNeuronal Plasticity Dynamic DNA methylation regulates neuronal intrinsic membrane excitability Jarrod P. Meadows1,*, Mikael C. Guzman-Karlsson1,*, Scott Phillips1, Jordan A. Brown1, Sarah K. Strange1, J. David Sweatt1,2,†, and John J. Hablitz1,‡1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.2Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.↵‡Corresponding author. Email: jhablitz{at}uab.edu↵* These authors contributed equally to this work.↵† Present address: Department of Pharmacology, Vanderbilt University, Nashville, TN 37235, USA. See allHide authors and affiliations Science Signaling 23 Aug 2016:Vol. 9, Issue 442, pp. ra83DOI: 10.1126/scisignal.aaf5642 Jarrod P. Meadows 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mikael C. Guzman-Karlsson 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Scott Phillips 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jordan A. Brown 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sarah K. Strange 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site J. David Sweatt 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.2Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site John J. Hablitz 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: jhablitz@uab.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 9 no. 442 ra83 DOI: https://doi.org/10.1126/scisignal.aaf5642 PubMed: 27555660 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received February 29, 2016Accepted August 5, 2016 . Copyright & Usage: Copyright © 2016, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2016 to April 2021 AbstractFullPdf Aug 20165212235420 Sep 201688653127 Oct 20162921252 Nov 20162211646 Dec 20161441321 Jan 20171221016 Feb 20171221028 Mar 20171101621 Apr 20171561321 May 20171361430 Jun 2017521124 Jul 20176958 Aug 2017118616 Sep 20171021225 Oct 201759918 Nov 2017104614 Dec 201757716 Jan 20188278 Feb 2018731522 Mar 20181383234 Apr 2018682835 May 2018713128 Jun 2018662521 Jul 2018282312 Aug 201806616 Sep 201807930 Oct 201807920 Nov 201808221 Dec 2018016618 Jan 2019410135 Feb 2019911323 Mar 2019614025 Apr 201915122 May 201947030 Jun 201943317 Jul 201932819 Aug 201972622 Sep 201924315 Oct 201984732 Nov 201924312 Dec 201954530 Jan 202035521 Feb 202002816 Mar 202035237 Apr 202026232 May 202054216 Jun 202024029 Jul 202094012 Aug 202023625 Sep 202066610 Oct 2020410533 Nov 202025622 Dec 202046634 Jan 202115022 Feb 202124523 Mar 202103627 Apr 2021165 View Full Text
Dynamic DNA methylation regulates neuronal intrinsic membrane excitability By Jarrod P. Meadows, Mikael C. Guzman-Karlsson, Scott Phillips, Jordan A. Brown, Sarah K. Strange, J. David Sweatt, John J. Hablitz Science Signaling23 Aug 2016 : ra83 The intrinsic excitability of cortical pyramidal neurons is set by dynamic DNA cytosine methylation.
Dynamic DNA methylation regulates neuronal intrinsic membrane excitability By Jarrod P. Meadows, Mikael C. Guzman-Karlsson, Scott Phillips, Jordan A. Brown, Sarah K. Strange, J. David Sweatt, John J. Hablitz Science Signaling23 Aug 2016 : ra83 The intrinsic excitability of cortical pyramidal neurons is set by dynamic DNA cytosine methylation.