Contents
30 August 2016
Vol 9, Issue 443
Vol 9, Issue 443
Contents
Research Article
- Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages
Macrophages exhibit distinct phenotypes when a shared receptor is stimulated by molecules associated with either infection or injury.
Research Resource
- Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells
Arginine methylation is prevalent throughout the proteome and regulates the localization and function of splicing and RNA transport factors.
Meeting Report
- Quantitative human cell encyclopedia
Quantitative cataloging of molecular entities in human cells will enable a better understanding of human physiology.
Podcast
- Science Signaling Podcast for 30 August 2016: Human arginine methylome
The human arginine methylome reveals the extent and importance of this posttranslational modification.
Editors' Choice
- A lock that cuts its own key
DWARF14 is a strigolactone receptor that hydrolyzes its ligand but remains covalently bound to one of the reaction products.
- WNK1 inhibits T cell adhesion
The kinase WNK1 inhibits the integrin-mediated adhesion of T cells and promotes their migration.
- PDAC puts its neighbors to work
Mitochondria in pancreatic tumor cells use alanine released by pancreatic stellate cells undergoing autophagy in the nutrient-poor microenvironment.
- DNA memories for mating
The process of transcribing a long noncoding RNA lets yeast control the response to mating signals.
- Paper of note in Science
This week’s article shows how hypoxia controls activity of the kinase Akt.
- Papers of note in Science Translational Medicine
This week’s articles describe potential strategies to suppress chronic inflammation and myeloma-induced bone destruction.
About The Cover
Online Cover This week features a Research Resource that used quantitative proteomics and high-content single-cell imaging to investigate the prevalence and functional consequences of arginine methylation. The image shows a network of RNA-binding protein complexes that are regulated by arginine methylation. [Image: Sara C. Larsen, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark]