POSTTRANSLATIONAL MODIFICATIONS
How hypoxia controls the kinase Akt
The Akt protein kinase is regulated by prolyl hydroxylation.
J. Guo, A. A. Chakraborty, P. Liu, W. Gan, X. Zheng, H. Inuzuka, B. Wang, J. Zhang, L. Zhang, M. Yuan, J. Novak, J. Q. Cheng, A. Toker, S. Signoretti, Q. Zhang, J. M. Asara, W. G. Kaelin Jr., W. Wei, pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner. Science 353, 929–932 (2016). [Abstract]
M. Voulgarelis, P. N. Tsichlis, Proline hydroxylation linked to Akt activation. Science 353, 870–871 (2016). [Summary]
