AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Noah I. Hornick; Ben Doron; Sherif Abdelhamed; Jianya Huan; Christina A. Harrington; Rongkun Shen; Xiaolu A. Cambronne; Santhosh Chakkaramakkil Verghese; Peter Kurre

doi:10.1126/scisignal.aaf2797

Research ArticleCANCER EXOSOMES

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Noah I. Hornick¹,²,³,*,
Ben Doron¹,²,³,*,
Sherif Abdelhamed¹,²,³,
Jianya Huan¹,²,⁴,
Christina A. Harrington⁴,⁵,
Rongkun Shen⁶,⁷,⁸,
Xiaolu A. Cambronne⁷,
Santhosh Chakkaramakkil Verghese¹,²,³, and
Peter Kurre¹,²,³,⁴,†

¹Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
²Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
³Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
⁵Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.
⁶Department of Biology, State University of New York, Brockport, NY 14420, USA.
⁷Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
⁸The College at Brockport, State University of New York, Brockport, NY 14420, USA.

↵†Corresponding author. Email: kurrepe{at}ohsu.edu

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Signaling 06 Sep 2016:
Vol. 9, Issue 444, pp. ra88
DOI: 10.1126/scisignal.aaf2797

Noah I. Hornick

Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ben Doron

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sherif Abdelhamed

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jianya Huan

Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christina A. Harrington

Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rongkun Shen

Department of Biology, State University of New York, Brockport, NY 14420, USA.Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.The College at Brockport, State University of New York, Brockport, NY 14420, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xiaolu A. Cambronne

Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Santhosh Chakkaramakkil Verghese

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter Kurre

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: kurrepe@ohsu.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Plain text

Vertical Tabs

Science Signaling

Article Tools