AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Noah I. Hornick; Ben Doron; Sherif Abdelhamed; Jianya Huan; Christina A. Harrington; Rongkun Shen; Xiaolu A. Cambronne; Santhosh Chakkaramakkil Verghese; Peter Kurre

doi:10.1126/scisignal.aaf2797

Research ArticleCANCER EXOSOMES

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Noah I. Hornick¹,²,³,*,
Ben Doron¹,²,³,*,
Sherif Abdelhamed¹,²,³,
Jianya Huan¹,²,⁴,
Christina A. Harrington⁴,⁵,
Rongkun Shen⁶,⁷,⁸,
Xiaolu A. Cambronne⁷,
Santhosh Chakkaramakkil Verghese¹,²,³, and
Peter Kurre¹,²,³,⁴,†

¹Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
²Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
³Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
⁵Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.
⁶Department of Biology, State University of New York, Brockport, NY 14420, USA.
⁷Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
⁸The College at Brockport, State University of New York, Brockport, NY 14420, USA.

↵†Corresponding author. Email: kurrepe{at}ohsu.edu

↵* These authors contributed equally to this work.

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Science Signaling 06 Sep 2016:
Vol. 9, Issue 444, pp. ra88
DOI: 10.1126/scisignal.aaf2797

Noah I. Hornick

1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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Ben Doron

1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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Sherif Abdelhamed

1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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Jianya Huan

1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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Christina A. Harrington

4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

5Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.

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Rongkun Shen

6Department of Biology, State University of New York, Brockport, NY 14420, USA.

7Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.

8The College at Brockport, State University of New York, Brockport, NY 14420, USA.

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Xiaolu A. Cambronne

7Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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Santhosh Chakkaramakkil Verghese

1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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Peter Kurre

1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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For correspondence: kurrepe@ohsu.edu

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AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

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