Research ArticleCANCER EXOSOMES
AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB
- Noah I. Hornick1,2,3,*,
- Ben Doron1,2,3,*,
- Sherif Abdelhamed1,2,3,
- Jianya Huan1,2,4,
- Christina A. Harrington4,5,
- Rongkun Shen6,7,8,
- Xiaolu A. Cambronne7,
- Santhosh Chakkaramakkil Verghese1,2,3, and
- Peter Kurre1,2,3,4,†
- 1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
- 2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
- 3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
- 4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
- 5Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.
- 6Department of Biology, State University of New York, Brockport, NY 14420, USA.
- 7Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
- 8The College at Brockport, State University of New York, Brockport, NY 14420, USA.
- ↵†Corresponding author. Email: kurrepe{at}ohsu.edu
↵* These authors contributed equally to this work.
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Science Signaling 06 Sep 2016:
Vol. 9, Issue 444, pp. ra88
DOI: 10.1126/scisignal.aaf2797
Vol. 9, Issue 444, pp. ra88
DOI: 10.1126/scisignal.aaf2797
Noah I. Hornick
1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Ben Doron
1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Sherif Abdelhamed
1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Jianya Huan
1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Christina A. Harrington
4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
5Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.
Rongkun Shen
6Department of Biology, State University of New York, Brockport, NY 14420, USA.
7Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
8The College at Brockport, State University of New York, Brockport, NY 14420, USA.
Xiaolu A. Cambronne
7Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Santhosh Chakkaramakkil Verghese
1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Peter Kurre
1Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
2Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.
3Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.
4Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
