Editors' ChoiceDiabetes

Paper of note in Science Translational Medicine

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Science Signaling  20 Sep 2016:
Vol. 9, Issue 446, pp. ec218
DOI: 10.1126/scisignal.aaj2264


IL-6 signaling implicated in diabetes

T cells from diabetic individuals are hyperresponsive to IL-6 stimulation, which could contribute to disease pathogenesis and may be an avenue for therapeutic intervention.

C. Hundhausen, A. Roth, E. Whalen, J. Chen, A. Schneider, S. A. Long, S. Wei, R. Rawlings, M. Kinsman, S. P. Evanko, T. N. Wight, C. J. Greenbaum, K. Cerosaletti, J. H. Buckner, Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression. Sci. Transl. Med. 8, 356ra119 (2016). [Abstract]

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