AUTOIMMUNITY
IL-6 signaling implicated in diabetes
T cells from diabetic individuals are hyperresponsive to IL-6 stimulation, which could contribute to disease pathogenesis and may be an avenue for therapeutic intervention.
C. Hundhausen, A. Roth, E. Whalen, J. Chen, A. Schneider, S. A. Long, S. Wei, R. Rawlings, M. Kinsman, S. P. Evanko, T. N. Wight, C. J. Greenbaum, K. Cerosaletti, J. H. Buckner, Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression. Sci. Transl. Med. 8, 356ra119 (2016). [Abstract]
