Contents
27 September 2016
Vol 9, Issue 447
Vol 9, Issue 447
Contents
Research Articles
- Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells
Blocking tumor-derived cytokine signaling in dendritic cells enables engineered dendritic cells to function as an antitumor vaccine.
- Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling
Two soluble binding proteins that differ in inhibitory ability and abundance fine-tune signaling by the cytokine interleukin-22.
- The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100
The NF-κB subunit RelB determines whether inhibitory or transcriptionally active complexes are formed during noncanonical signaling.
Editors' Choice
- Immunosuppression even in death
Dying tumor cells release potassium ions that suppress the activity of tumor-infiltrating T cells.
- One way fumarate can promote metastasis
Accumulation of the metabolite fumarate induces epigenetic changes that promote the epithelial-to-mesenchymal transition.
- Inhibiting the inflammasome
The kinase PKA phosphorylates and inactivates the NLRP3 inflammasome to restrain inflammation.
- Lupus and leptin
The hormone and cytokine leptin promotes disease progression in mouse models of systemic lupus erythematosus.
- Papers of note in Science and Science Immunology
This week’s articles describe how commensal bacteria can induce tolerance to pathogenic bacteria and how a thermosensory circuit in the brain senses thermal stress.
- Paper of note in Science Translational Medicine
This week’s article describes how natural killer cells might be harnessed as a new immunotherapy to treat patients with acute myeloid leukemia.
About The Cover
Online Cover This week features a Research Article that describes how engineering antitumor vaccines with STAT3-deficient dendritic cells might improve the outcome of immunotherapy in melanoma patients. The image shows an artist's rendition of dendritic cells and T lymphocytes. [Image: iStock/96845425]