HOST-MICROBE INTERACTIONS
Microbes teach tolerance in the gut
Pathogenic salmonella can be tolerated in the presence of a commensal bacterium that promotes gut barrier function.
K. J. Rangan, V. A. Pedicord, Y.-C. Wang, B. Kim, Y. Lu, S. Shaham, D. Mucida, H. C. Hang, A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. Science 353, 1434–1437 (2016). [Abstract]
V. A. Pedicord, A. A. K. Lockhart, K. J. Rangan, J. W. Craig, J. Loschko, A. Rogoz, H. C. Hang, D. Mucida, Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance. Sci. Immunol. 1, eaai7732 (2016). [Abstract]
NEUROSCIENCE
How brain neurons turn down the heat
Thermal stress is detected and core body temperature is controlled by a thermosensory circuit in the brain.
K. Song, H. Wang, G. B. Kamm, J. Pohle, F. de Castro Reis, P. Heppenstall, H. Wende, J. Siemens, The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
Science 353, 1393–1398 (2016). [Abstract]
T. Bartfai, Cool by neuronal decision. Science 353, 1363–1364 (2016). [Abstract]
