Contents
04 October 2016
Vol 9, Issue 448
Vol 9, Issue 448
Contents
Focus
- New twists in the AXL(e) of tumor progression
AXL inhibitors may slow tumor progression in patients with a mesenchymal subtype of ovarian cancer (Antony et al., in 4 October 2016 issue).
Research Articles
- The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype–specific therapeutic target for ovarian cancer
AXL inhibitors may prolong survival in a subset of patients with advanced ovarian cancer.
- Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
Blocking JNK signaling halts neuroinflammation caused by infection with Japanese encephalitis virus.
- Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity
The tyrosine phosphatase PTPN22 redistributes from clusters to the leading edge in migrating T cells to inhibit integrin-mediated adhesion.
Editors' Choice
- Arresting migrating neutrophils with ROS
Oxidation of TRPM2 by ROS at sites of inflammation may limit tissue damage caused by neutrophils.
- Surviving the flood
Plants use a MAPKKK-dependent pathway to control the permeability of roots to water.
- A uniquely human susceptibility to bacterial infection
A sialic acid that is abundant in human mucus enhances Streptococcus pneumoniae virulence.
- Papers of note in Science Translational Medicine
This week’s articles highlight a lipokine that limits atherosclerosis, biomaterials for bone regeneration, and a cytokine associated with malaria pathogenesis.
- Papers of note in Science
This week’s articles describe a mechanism for the propagation of protein aggregates associated with Parkinson’s disease, crosstalk between fat cells and the brain that controls the growth of fruit flies, a histone brake on tumor growth, the coordination of DNA repair with the cell cycle, and a role for the innate immune response in liver damage caused by hepatitis A infection.
- Regulating the rate of mRNA degradation
Histone acetyltransferases and deacetylases control mRNA stability.
- Limiting damage but promoting resistance
A transient response to chemotherapy in the vasculature promotes chemoresistance in lymphoma cells.
Errata
- Erratum for the Research Article: “Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML” by I. Morgado-Palacin, A. Day, M. Murga, V. Lafarga, M. E. Anton, A. Tubbs, H.-T. Chen, A. Ergan, R. Anderson, A. Bhandoola, K. G. Pike, B. Barlaam, E. Cadogan, X. Wang, A. J. Pierce, C. Hubbard, S. A. Armstrong, A. Nussenzweig, O. Fernandez-Capetillo
An author’s last name is corrected and middle initial is inserted. A closing parenthesis in a sentence in the Abstract has also been added.
About The Cover
Online Cover This week features a Research Article that demonstrates how phosphoproteomic analysis can lead to treatment strategies to prevent damaging neuroinflammation caused by Japanese encephalitis virus, a mosquito-borne virus related to dengue and Zika. The image shows activated microglia in the brain of an infected mouse. [Image: Jing Ye/Huazhong Agricultural University, China]