Contents

Contents

• Focus

  • New twists in the AXL(e) of tumor progression

    By Balazs Halmos, Eric B. Haura

    Science Signaling04 Oct 2016 : fs14 Full AccessRestricted Access

    AXL inhibitors may slow tumor progression in patients with a mesenchymal subtype of ovarian cancer (Antony et al., in 4 October 2016 issue).

    • Abstract
    • Full Text
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• Research Articles

  • The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype–specific therapeutic target for ovarian cancer

    By Jane Antony, Tuan Zea Tan, Zoe Kelly, Jeffrey Low, Mahesh Choolani, Chiara Recchi, Hani Gabra, Jean Paul Thiery, Ruby Yun-Ju Huang

    Science Signaling04 Oct 2016 : ra97 Full AccessRestricted Access

    AXL inhibitors may prolong survival in a subset of patients with advanced ovarian cancer.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus

    By Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao

    Science Signaling04 Oct 2016 : ra98 Full AccessRestricted Access

    Blocking JNK signaling halts neuroinflammation caused by infection with Japanese encephalitis virus.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

    By Garth L. Burn, Georgina H. Cornish, Katarzyna Potrzebowska, Malin Samuelsson, Juliette Griffié, Sophie Minoughan, Mark Yates, George Ashdown, Nicolas Pernodet, Vicky L. Morrison, Cristina Sanchez-Blanco, Harriet Purvis, Fiona Clarke, Rebecca J. Brownlie, Timothy J. Vyse, Rose Zamoyska, Dylan M. Owen, Lena M. Svensson, Andrew P. Cope

    Science Signaling04 Oct 2016 : ra99 Full AccessRestricted Access

    The tyrosine phosphatase PTPN22 redistributes from clusters to the leading edge in migrating T cells to inhibit integrin-mediated adhesion.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Editors' Choice

  • Arresting migrating neutrophils with ROS

    By Wei Wong

    Science Signaling04 Oct 2016 : ec226 Full AccessRestricted Access

    Oxidation of TRPM2 by ROS at sites of inflammation may limit tissue damage caused by neutrophils.

    • Abstract

  • Surviving the flood

    By Nancy R. Gough

    Science Signaling04 Oct 2016 : ec227 Full AccessRestricted Access

    Plants use a MAPKKK-dependent pathway to control the permeability of roots to water.

    • Abstract

  • A uniquely human susceptibility to bacterial infection

    By Annalisa M. VanHook

    Science Signaling04 Oct 2016 : ec228 Full AccessRestricted Access

    A sialic acid that is abundant in human mucus enhances Streptococcus pneumoniae virulence.

    • Abstract

  • Papers of note in Science Translational Medicine

    By Leslie K. Ferrarelli

    Science Signaling04 Oct 2016 : ec229 Full AccessRestricted Access

    This week’s articles highlight a lipokine that limits atherosclerosis, biomaterials for bone regeneration, and a cytokine associated with malaria pathogenesis.

    • Abstract

  • Papers of note in Science

    By Annalisa M. VanHook

    Science Signaling04 Oct 2016 : ec230 Full AccessRestricted Access

    This week’s articles describe a mechanism for the propagation of protein aggregates associated with Parkinson’s disease, crosstalk between fat cells and the brain that controls the growth of fruit flies, a histone brake on tumor growth, the coordination of DNA repair with the cell cycle, and a role for the innate immune response in liver damage caused by hepatitis A infection.

    • Abstract

  • Regulating the rate of mRNA degradation

    By Alexandra A. Mushegian

    Science Signaling04 Oct 2016 : ec231 Full AccessRestricted Access

    Histone acetyltransferases and deacetylases control mRNA stability.

    • Abstract

  • Limiting damage but promoting resistance

    By Leslie K. Ferrarelli

    Science Signaling04 Oct 2016 : ec232 Full AccessRestricted Access

    A transient response to chemotherapy in the vasculature promotes chemoresistance in lymphoma cells.

    • Abstract

• Errata

  • Erratum for the Research Article: “Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter” by K. T. Kahle, B. Flores, D. Bharucha-Goebel, J. Zhang, S. Donkervoort, M. Hegde, G. Hussain, D. Duran, B. Liang, D. Sun, C. G. Bönnemann, E. Delpire

    Science Signaling04 Oct 2016 : er1 Full AccessRestricted Access

    An author’s name is corrected.

    • Full Text

  • Erratum for the Research Article: “Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML” by I. Morgado-Palacin, A. Day, M. Murga, V. Lafarga, M. E. Anton, A. Tubbs, H.-T. Chen, A. Ergan, R. Anderson, A. Bhandoola, K. G. Pike, B. Barlaam, E. Cadogan, X. Wang, A. J. Pierce, C. Hubbard, S. A. Armstrong, A. Nussenzweig, O. Fernandez-Capetillo

    Science Signaling04 Oct 2016 : er2 Full AccessRestricted Access

    An author’s last name is corrected and middle initial is inserted. A closing parenthesis in a sentence in the Abstract has also been added.

    • Full Text