ATHEROSCLEROSIS
Artery-saving fat
A bioactive lipokine promotes metabolic resilience of organelles and limits the progression of atherosclerosis.
I. Çimen, B. Kocatürk, S. Koyuncu, Ö. Tufanlı, U. I. Onat, A. D. Yıldırım, O. Apaydın, Ş. Demirsoy, Z. G. Aykut, U. T. Nguyen, S. M. Watkins, G. S. Hotamışlıgil, E. Erbay, Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Sci. Transl. Med. 8, 358ra126 (2016). [Abstract]
BIOMATERIALS
Building better bones
A new, mechanically elastic biomaterial can be custom 3D-printed, is surgically friendly, and promotes robust bone regeneration.
A. E. Jakus, A. L. Rutz, S. W. Jordan, A. Kannan, S. M. Mitchell, C. Yun, K. D. Koube, S. C. Yoo, H. E. Whiteley, C.-P. Richter, R. D. Galiano, W. K. Hsu, S. R. Stock, E. L. Hsu, R. N. Shah, Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial. Sci. Transl. Med. 8, 358ra127 (2016). [Abstract]
MALARIA
Bolstering the host to beat malaria
Angiopoietin-1 is dysregulated in pediatric severe malaria, and targeting it prevents vascular dysfunction and death in a mouse model of cerebral malaria.
S. J. Higgins, L. A. Purcell, K. L. Silver, V. Tran, V. Crowley, M. Hawkes, A. L. Conroy, R. O. Opoka, J. G. Hay, S. E. Quaggin, G. Thurston, W. C. Liles, K. C. Kain, Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Sci. Transl. Med. 8, 358ra128 (2016). [Abstract]
