Research ArticleViral Infection Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus Jing Ye1,2,3,4, Hao Zhang1,2,4, Wen He1,2,4, Bibo Zhu1,2,4, Dengyuan Zhou1,2,4, Zheng Chen1,2,4, Usama Ashraf1,2,4, Yanming Wei1,2,4, Ziduo Liu1,3, Zhen F. Fu1,2,5, Huanchun Chen1,2,4, and Shengbo Cao1,2,4,*1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.3College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.5Department of Pathology, University of Georgia, Athens, GA 30602, USA.↵*Corresponding author. Email: sbcao{at}mail.hzau.edu.cn See allHide authors and affiliations Science Signaling 04 Oct 2016:Vol. 9, Issue 448, pp. ra98DOI: 10.1126/scisignal.aaf5132 Jing Ye 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.3College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Hao Zhang 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Wen He 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Bibo Zhu 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Dengyuan Zhou 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Zheng Chen 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Usama Ashraf 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yanming Wei 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ziduo Liu 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.3College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Zhen F. Fu 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.5Department of Pathology, University of Georgia, Athens, GA 30602, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Huanchun Chen 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Shengbo Cao 1State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.2Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.4The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: sbcao@mail.hzau.edu.cn Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 9 no. 448 ra98 DOI: https://doi.org/10.1126/scisignal.aaf5132 PubMed: 27703031 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received February 21, 2016Accepted September 15, 2016 . Copyright & Usage: Copyright © 2016, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: September 2016 to February 2021 AbstractFullPdf Sep 2016431 Oct 20164696262471 Nov 20163244285 Dec 20161791727 Jan 20171681117 Feb 20172131325 Mar 2017128910 Apr 2017137921 May 2017103712 Jun 2017941030 Jul 20178189 Aug 20176817 Sep 20175784 Oct 201790109 Nov 201710399 Dec 20177268 Jan 201810247 Feb 2018971314 Mar 2018741320 Apr 20187588 May 201810055 Jun 201887112 Jul 201877117 Aug 201863196 Sep 2018902613 Oct 2018617452 Nov 2018472610 Dec 201858164 Jan 2019553513 Feb 2019108167 Mar 20191471410 Apr 2019181226 May 20191372512 Jun 2019176126 Jul 2019319159 Aug 20196241915 Sep 2019754194 Oct 2019513238 Nov 2019358104 Dec 201923073 Jan 202039215 Feb 20204375 Mar 202052116 Apr 20205862 May 20204497 Jun 2020102323 Jul 202035145 Aug 20203178 Sep 202030188 Oct 202062144 Nov 20204583 Dec 2020441915 Jan 202132103 Feb 20212842 View Full Text
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus By Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao Science Signaling04 Oct 2016 : ra98 Blocking JNK signaling halts neuroinflammation caused by infection with Japanese encephalitis virus. Supplementary Materials
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus By Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao Science Signaling04 Oct 2016 : ra98 Blocking JNK signaling halts neuroinflammation caused by infection with Japanese encephalitis virus. Supplementary Materials