Editors' ChoiceCell death

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Science Signaling  11 Oct 2016:
Vol. 9, Issue 449, pp. ec236
DOI: 10.1126/scisignal.aal1595


DNA damage–activated nuclease identified

An endonuclease that functions in a disease-associated form of cell death is identified.

Y. Wang, R. An, G. K. Umanah, H. Park, K. Nambiar, S. M. Eacker, B. Kim, L. Bao, M. M. Harraz, C. Chang, R. Chen, J. E. Wang, T.-I. Kam, J. S. Jeong, Z. Xie, S. Neifert, J. Qian, S. A. Andrabi, S. Blackshaw, H. Zhu, H. Song, G.-l. Ming, V. L. Dawson, T. M. Dawson, A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science 353, aad6872 (2016). [Abstract]

E. Jonas, The MIFstep in parthanatos. Science 353, 36–37 (2016). [Abstract]

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