CANCER
Stiff resistance to cancer therapy
Anti-VEGF therapy enhances mechanical barriers to therapy in colorectal cancer liver metastases by increasing hyaluronan deposition.
N. N. Rahbari, D. Kedrin, J. Incio, H. Liu, W. W. Ho, H. T. Nia, C. M. Edrich, K. Jung, J. Daubriac, I. Chen, T. Heishi, J. D. Martin, Y. Huang, N. Maimon, C. Reissfelder, J. Weitz, Y. Boucher, J. W. Clark, A. J. Grodzinsky, D. G. Duda, R. K. Jain, D. Fukumura, Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci. Transl. Med. 8, 360ra135 (2016). [Abstract]
