Editors' ChoicePosttranslational modification

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Science Signaling  18 Oct 2016:
Vol. 9, Issue 450, pp. ec243
DOI: 10.1126/scisignal.aal2123


A function for multisite phosphorylation

Transcription factors are regulated by multisite phosphorylation that both potentiates and limits transcriptional activation.

A. Mylona, F.-X. Theillet, C. Foster, T. M. Cheng, F. Miralles, P. A. Bates, P. Selenko, R. Treisman, Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation. Science 354, 233–237 (2016). [Abstract]

A. J. Whitmarsh, R. J. Davis, Multisite phosphorylation by MAPK. Science 354, 179–180 (2016). [Abstract]


Phosphorylation and fungal evolution

Phosphorylation in fungal proteins offers an understanding of evolutionary constraints acting on posttranscriptional modification.

R. A. Studer, R. A. Rodriguez-Mias, K. M. Haas, J. I. Hsu, C. Viéitez, C. Solé, D. L. Swaney, L. B. Stanford, I. Liachko, R. Böttcher, M. J. Dunham, E. de Nadal, F. Posas, P. Beltrao, J. Villén, Evolution of protein phosphorylation across 18 fungal species. Science 354, 229–232 (2016). [Abstract]

O. Matalon, B. Dubreuil, E. D. Levy, Young phosphorylation is functionally silent. Science 354, 176–177 (2016). [Abstract]

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