VASCULAR DISEASE
Wreaking havoc while (growth-)arrested
Senescent macrophages contribute to early and late stages of atherosclerosis and are potential targets for therapy.
B. G. Childs, D. J. Baker, T. Wijshake, C. A. Conover, J. Campisi, J. M. van Deursen, Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science 354, 472–477 (2016). [Abstract]
IMMUNOMETABOLISM
Metabolic support for T cell functions
Immunological T cell effector functions are promoted by metabolic activity–modifying levels of histone acetylation.
M. Peng, N. Yin, S. Chhangawala, K. Xu, C. S. Leslie, M. O. Li, Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science 354, 481–484 (2016). [Abstract]
METABOLISM
Quantitation of metabolic pathway regulation
Metabolomics, proteomics, and flux analysis are used to dissect quantitatively metabolic regulation in living yeast.
S. R. Hackett, V. R. T. Zanotelli, W. Xu, J. Goya, J. O. Park, D. H. Perlman, P. A. Gibney, D. Botstein, J. D. Storey, J. D. Rabinowitz, Systems-level analysis of mechanisms regulating yeast metabolic flux. Science 354, aaf2786 (2016). [Abstract]
CELLULAR STRUCTURE
A dynamic view of the endoplasmic reticulum
Superresolution imaging shows that presumed sheets of endoplasmic reticulum comprise tightly packed, constantly changing tubules.
J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, J. Lippincott-Schwartz, Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. Science 354, aaf3928 (2016). [Abstract]
M. Terasaki, A finer look at a fine cellular meshwork.Science 354, 415–416 (2016). [Abstract]
GENE EXPRESSION
Plunging into a domain of silence
A noncoding RNA recruits the X chromosome to the nuclear periphery, spreading across the chromosome and silencing gene expression.
C.-K. Chen, M. Blanco, C. Jackson, E. Aznauryan, N. Ollikainen, C. Surka, A. Chow, A. Cerase, P. McDonel, M. Guttman, Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science 354, 468–472 (2016). [Abstract]
