Editors' ChoiceCellular and Molecular Signaling

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Science Signaling  01 Nov 2016:
Vol. 9, Issue 452, pp. ec259
DOI: 10.1126/scisignal.aal2954


Wreaking havoc while (growth-)arrested

Senescent macrophages contribute to early and late stages of atherosclerosis and are potential targets for therapy.

B. G. Childs, D. J. Baker, T. Wijshake, C. A. Conover, J. Campisi, J. M. van Deursen, Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science 354, 472–477 (2016). [Abstract]


Metabolic support for T cell functions

Immunological T cell effector functions are promoted by metabolic activity–modifying levels of histone acetylation.

M. Peng, N. Yin, S. Chhangawala, K. Xu, C. S. Leslie, M. O. Li, Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science 354, 481–484 (2016). [Abstract]


Quantitation of metabolic pathway regulation

Metabolomics, proteomics, and flux analysis are used to dissect quantitatively metabolic regulation in living yeast.

S. R. Hackett, V. R. T. Zanotelli, W. Xu, J. Goya, J. O. Park, D. H. Perlman, P. A. Gibney, D. Botstein, J. D. Storey, J. D. Rabinowitz, Systems-level analysis of mechanisms regulating yeast metabolic flux. Science 354, aaf2786 (2016). [Abstract]


A dynamic view of the endoplasmic reticulum

Superresolution imaging shows that presumed sheets of endoplasmic reticulum comprise tightly packed, constantly changing tubules.

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, J. Lippincott-Schwartz, Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. Science 354, aaf3928 (2016). [Abstract]

M. Terasaki, A finer look at a fine cellular meshwork.Science 354, 415–416 (2016). [Abstract]


Plunging into a domain of silence

A noncoding RNA recruits the X chromosome to the nuclear periphery, spreading across the chromosome and silencing gene expression.

C.-K. Chen, M. Blanco, C. Jackson, E. Aznauryan, N. Ollikainen, C. Surka, A. Chow, A. Cerase, P. McDonel, M. Guttman, Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science 354, 468–472 (2016). [Abstract]

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