Contents
15 November 2016
Vol 9, Issue 454
Vol 9, Issue 454
Contents
Editorial Guide
- Focus Issue: New horizons for treating neurological disease
Kinases and protein interaction networks offer new strategies and experimental targets to treat neurological disease.
Research Articles
- A unique type of GSK-3 inhibitor brings new opportunities to the clinic
A substrate peptide that the kinase GSK-3 converts into its own inhibitor improves symptoms and cognitive function in an Alzheimer’s disease model.
- RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network (“Rhesactome”) in the striatum
Protein interaction networks of the GTPase Rhes regulate motor control in the striatum.
Podcast
- Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor
A peptide that inhibits the kinase GSK-3 improves symptoms in a mouse model of Alzheimer’s disease (Licht-Murava et al., in 15 November 2016 issue).
Editors' Choice
- A tRNA synthetase protects MAVS
A tRNA synthetase enhances the immune response to RNA viruses by protecting the antiviral signaling protein MAVS from degradation.
- Auxin signaling without Aux/IAAs
Auxin regulates the interaction of the transcription factor ETTIN (also known as ARF3) with other developmentally important transcription factors.
- A ribosomal strategy for magnesium deficiency
Under low-magnesium stress, bacteria suppress ribosome synthesis.
- Inhibiting the insulin receptor with galectin3
Obesity-associated insulin resistance may be caused by a lectin released by macrophages that blocks insulin receptor signaling.
- Paper of note in Science Immunology
This week’s article shows that by inducing expression of the gene encoding the transcription factor Blimp-1, the cytokine IL-10 restrains autoimmune responses.
- Paper of note in Science Translational Medicine
This week’s paper describes how a CXCL12-trapping nanoparticle may prevent liver metastasis.
- Papers of note in Science
This week’s articles highlight the involvement of a cytosolic DNA sensor in the response to radiation-induced DNA damage, a peptide that can inhibit tumor growth by causing a growth factor receptor to form amyloid aggregates, and the importance of endogenous RNA interference in maintaining cell quiescence.
About The Cover
Online Cover This week, the journal focuses on neuroscience (see Editorial Guide ) and features a Research Article that identifies a protein interaction network of the GTPase Rhes in the striatum that may regulate motor control. The image shows an abstract rendition of regional networks in the brain. [Image: airiesummer/iStockphoto.com]