CYTOKINES
Regulating Blimp-1 in TH2 cells
STAT3-mediated Blimp-1 induction in T cells antagonizes STAT5’s role in promoting cell cycle and cell survival genes.
A. C. Poholek, D. Jankovic, A. V. Villarino, F. Petermann, A. Hettinga, D. S. Shouval, S. B. Snapper, S. M. Kaech, S. R. Brooks, G. Vahedi, A. Sher, Y. Kanno, J. J. O’Shea, IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci. Immunol. 1, eaaf8612 (2016). [Abstract]
