Editors' ChoicePharmacology

Paper of note in Science Translational Medicine

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Science Signaling  15 Nov 2016:
Vol. 9, Issue 454, pp. ec272
DOI: 10.1126/scisignal.aal3829


Trapping a prometastatic signal

Targeted nanoparticles induce expression of a CXCL12/SDF-1 trap in a transient and liver-specific manner to inhibit colorectal cancer liver metastasis.

T. J. Goodwin, Y. Zhou, S. N. Musetti, R. Liu, L. Huang, Local and transient gene expression primes the liver to resist cancer metastasis. Sci. Transl. Med. 8, 364ra153 (2016). [Abstract]

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