Contents
22 November 2016
Vol 9, Issue 455
Vol 9, Issue 455
Contents
Research Articles
- Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin
Transcriptomic analysis and mathematical modeling reveal selective gene regulation by insulin.
- A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia
A ligand-targeted compound may alleviate hypophosphatemia-associated metabolic deficiencies in patients with excess production of FGF-23.
- Integrating network reconstruction with mechanistic modeling to predict cancer therapies
Unexpected drug combinations for cancer treatment emerge from modeling signaling pathways affected by genomic mutations.
Editors' Choice
- A noncanonical role for Janus kinase 1 in lymphoma
JAK1-dependent chromatin phosphorylation promotes the survival of aggressive lymphoma cells.
- TRAF6 targets p53
TRAF6-mediated ubiquitylation of p53 regulates both mitochondrial apoptosis and cell cycle arrest.
- Cancer, host metabolism, and immunotherapy
Tumor-induced metabolic stress associated with cachexia suppresses the antitumor immune response in mice.
- Activating the MAPK pathway with a kinase instead of a GTPase
The kinase PBL27 links activation of a pathogen recognition receptor to activation of immune signaling in Arabidopsis thaliana.
- Papers of note in Science
This week’s articles show that some plant photoreceptors can also detect temperature, enzymes that synthesize a plant defense metabolite assemble on demand, not all phosphorylation of tau promotes neurodegeneration, and neurons thought to be part of the parasympathetic nervous system are actually sympathetic.
About The Cover
Online Cover This week features a Research Article that computationally identifies a ligand-targeted compound that may alleviate hypophosphatemia, vitamin D deficiency and parathyroid hormone imbalance in disorders caused by excess FGF-23 production. The image shows a predictive model of the interaction of FGF-23 with the drug, Zinc13407541, superimposed on a computer screen. [Image: Demian Riccardi, Department of Chemistry, Earlham College, and Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville; Hector A. Velazquez and Jerome Baudry, Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, and University of Tennessee/Oak Ridge National Laboratory Center for Molecular Biophysics, Oak Ridge National Laboratory; baona/iStockphoto.com]