29 November 2016
Vol 9, Issue 456

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that the mitochondrial-associated protein MAVS, which normally aggregates in response to viral infection to induce type I interferon (IFN) production, can also aggregate in response to reactive oxygen species (ROS). A mutant MAVS protein that is associated with a milder form of systemic lupus erythematosus fails to aggregate in response to ROS, leading to less IFN production. The image shows a transmission electron micrograph of misshapen mitochondria in a fibroblast exposed to ROS. [Image: Iwona Buskiewicz, University of Vermont, Burlington, VT, USA]