DRUG DEVELOPMENT
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Single-domain antibodies called nanobodies block P2X7, an inflammatory ion channel, reducing skin and kidney inflammation in mice.
W. Danquah, C. Meyer-Schwesinger, B. Rissiek, C. Pinto, A. Serracant-Prat, M. Amadi, D. Iacenda, J.-H. Knop, A. Hammel, P. Bergmann, N. Schwarz, J. Assunção, W. Rotthier, F. Haag, E. Tolosa, P. Bannas, E. Boué-Grabot, T. Magnus, T. Laeremans, C. Stortelers, F. Koch-Nolte, Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. Sci. Transl. Med. 8, 366ra162 (2016). [Abstract]
GENETIC DISORDERS
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification
Tissue-specific manifestations of the congenital bone-forming syndrome FOP are mediated by multiple tissue-resident stem cell populations.
D. Dey, J. Bagarova, S. J. Hatsell, K. A. Armstrong, L. Huang, J. Ermann, A. J. Vonner, Y. Shen, A. H. Mohedas, A. Lee, E. M. W. Eekhoff, A. van Schie, M. B. Demay, C. Keller, A. J. Wagers, A. N. Economides, P. B. Yu, Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci. Transl. Med. 8, 366ra163 (2016). [Abstract]
