Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia

M. Frank Erasmus; Ksenia Matlawska-Wasowska; Ichiko Kinjyo; Avanika Mahajan; Stuart S. Winter; Li Xu; Michael Horowitz; Diane S. Lidke; Bridget S. Wilson

doi:10.1126/scisignal.aaf3949

Research ArticleImmunology

Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia

M. Frank Erasmus¹,²,
Ksenia Matlawska-Wasowska²,³,
Ichiko Kinjyo¹,²,
Avanika Mahajan¹,²,
Stuart S. Winter²,³,
Li Xu⁴,
Michael Horowitz⁴,
Diane S. Lidke¹,², and
Bridget S. Wilson¹,²,*

¹Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
²UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
³Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
⁴Sea Lane Biotechnologies, 2450 Bayshore Parkway, Mountain View, CA 94043, USA.

↵*Corresponding author. Email: bwilson{at}salud.unm.edu

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Science Signaling 29 Nov 2016:
Vol. 9, Issue 456, pp. ra116
DOI: 10.1126/scisignal.aaf3949

M. Frank Erasmus

1Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Ksenia Matlawska-Wasowska

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

3Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Ichiko Kinjyo

1Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Avanika Mahajan

1Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Stuart S. Winter

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

3Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Li Xu

4Sea Lane Biotechnologies, 2450 Bayshore Parkway, Mountain View, CA 94043, USA.

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Michael Horowitz

4Sea Lane Biotechnologies, 2450 Bayshore Parkway, Mountain View, CA 94043, USA.

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Diane S. Lidke

1Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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Bridget S. Wilson

1Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

2UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

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For correspondence: bwilson@salud.unm.edu

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Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia

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