1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
2Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
3Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
By Tarsis F. Brust, Jenny Morgenweck, Susy A. Kim, Jamie H. Rose, Jason L. Locke, Cullen L. Schmid, Lei Zhou, Edward L. Stahl, Michael D. Cameron, Sarah M. Scarry, Jeffrey Aubé, Sara R. Jones, Thomas J. Martin, Laura M. Bohn
Science Signaling : ra117
Biased agonists of the kappa opioid receptor may relieve intractable itch without causing unwanted side effects.
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
By Tarsis F. Brust, Jenny Morgenweck, Susy A. Kim, Jamie H. Rose, Jason L. Locke, Cullen L. Schmid, Lei Zhou, Edward L. Stahl, Michael D. Cameron, Sarah M. Scarry, Jeffrey Aubé, Sara R. Jones, Thomas J. Martin, Laura M. Bohn
Science Signaling : ra117
Biased agonists of the kappa opioid receptor may relieve intractable itch without causing unwanted side effects.