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vol. 9 no. 456 ra117
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History:
- Received August 19, 2016
- Accepted November 9, 2016
- .
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Copyright © 2016, American Association for the Advancement of Science
Research ArticlePharmacology
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
- Tarsis F. Brust1,
- Jenny Morgenweck1,
- Susy A. Kim2,
- Jamie H. Rose3,
- Jason L. Locke3,
- Cullen L. Schmid1,
- Lei Zhou1,
- Edward L. Stahl1,
- Michael D. Cameron1,
- Sarah M. Scarry4,
- Jeffrey Aubé4,
- Sara R. Jones3,
- Thomas J. Martin2, and
- Laura M. Bohn1,*
- 1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
- 2Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
- 3Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
- 4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- ↵*Corresponding author. Email: lbohn{at}scripps.edu
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Science Signaling 29 Nov 2016:
Vol. 9, Issue 456, pp. ra117
DOI: 10.1126/scisignal.aai8441
Vol. 9, Issue 456, pp. ra117
DOI: 10.1126/scisignal.aai8441
Tarsis F. Brust
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Jenny Morgenweck
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Susy A. Kim
2Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Jamie H. Rose
3Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Jason L. Locke
3Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Cullen L. Schmid
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Lei Zhou
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Edward L. Stahl
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Michael D. Cameron
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Sarah M. Scarry
4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jeffrey Aubé
4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sara R. Jones
3Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Thomas J. Martin
2Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Laura M. Bohn
1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
