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vol. 9 no. 456 ra117
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History:
- Received August 19, 2016
- Accepted November 9, 2016
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Copyright © 2016, American Association for the Advancement of Science
Research ArticlePharmacology
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
- Tarsis F. Brust1,
- Jenny Morgenweck1,
- Susy A. Kim2,
- Jamie H. Rose3,
- Jason L. Locke3,
- Cullen L. Schmid1,
- Lei Zhou1,
- Edward L. Stahl1,
- Michael D. Cameron1,
- Sarah M. Scarry4,
- Jeffrey Aubé4,
- Sara R. Jones3,
- Thomas J. Martin2, and
- Laura M. Bohn1,*
- 1Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
- 2Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
- 3Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
- 4Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- ↵*Corresponding author. Email: lbohn{at}scripps.edu
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Sci. Signal. 29 Nov 2016:
Vol. 9, Issue 456, pp. ra117
DOI: 10.1126/scisignal.aai8441
Vol. 9, Issue 456, pp. ra117
DOI: 10.1126/scisignal.aai8441
Tarsis F. Brust
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Jenny Morgenweck
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Susy A. Kim
Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Jamie H. Rose
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Jason L. Locke
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Cullen L. Schmid
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Lei Zhou
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Edward L. Stahl
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Michael D. Cameron
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Sarah M. Scarry
Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jeffrey Aubé
Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sara R. Jones
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Thomas J. Martin
Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Laura M. Bohn
Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
