Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Tarsis F. Brust; Jenny Morgenweck; Susy A. Kim; Jamie H. Rose; Jason L. Locke; Cullen L. Schmid; Lei Zhou; Edward L. Stahl; Michael D. Cameron; Sarah M. Scarry; Jeffrey Aubé; Sara R. Jones; Thomas J. Martin; Laura M. Bohn

doi:10.1126/scisignal.aai8441

Research ArticlePharmacology

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Tarsis F. Brust¹,
Jenny Morgenweck¹,
Susy A. Kim²,
Jamie H. Rose³,
Jason L. Locke³,
Cullen L. Schmid¹,
Lei Zhou¹,
Edward L. Stahl¹,
Michael D. Cameron¹,
Sarah M. Scarry⁴,
Jeffrey Aubé⁴,
Sara R. Jones³,
Thomas J. Martin², and
Laura M. Bohn¹,*

¹Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
²Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
³Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
⁴Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

↵*Corresponding author. Email: lbohn{at}scripps.edu

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Sci. Signal. 29 Nov 2016:
Vol. 9, Issue 456, pp. ra117
DOI: 10.1126/scisignal.aai8441

Tarsis F. Brust

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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Jenny Morgenweck

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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Susy A. Kim

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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Jamie H. Rose

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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Jason L. Locke

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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Cullen L. Schmid

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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Lei Zhou

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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Edward L. Stahl

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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Michael D. Cameron

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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Sarah M. Scarry

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Jeffrey Aubé

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Sara R. Jones

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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Thomas J. Martin

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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Laura M. Bohn

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.

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For correspondence: lbohn@scripps.edu

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Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

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