Contents
06 December 2016
Vol 9, Issue 457
Vol 9, Issue 457
Contents
Editorial Guide
- Emerging roles for organelles in cellular regulation
Organelles not only regulate cell behavior and function but are themselves regulated by internal and external signals.
Research Articles
- A TGFβ–miR-182–BRCA1 axis controls the mammary differentiation hierarchy
TGFβ promotes luminal differentiation of mammary stem cells by suppressing a BRCA1-targeting microRNA.
- Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides
A family of micropeptides inhibits calcium reuptake by the endoplasmic reticulum in diverse cell types.
- Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages
Macrophage-specific insulation of canonical NF-κB signaling from the noncanonical pathway prevents excessive inflammation.
Editors' Choice
- Circadian effects on immunization responses
Diurnal control of lymphocyte trafficking by adrenergic signaling determines the timing of effective immunization.
- Reducing nerve-damaging reactive metabolites
Nematode studies reveal the pathway that promotes detoxification of reactive α-dicarbonyls and drugs that can enhance this pathway.
- SUMO versus ubiquitin in Hedgehog signaling
SUMOylation of Smoothened promotes deubiquitylation, stabilizing Smoothened at the membrane.
- Bacteria stop fermentation with lactic acid
Bacteria release lactic acid, inducing a prion-based metabolic switch in yeast.
- Papers of note in Science
This week’s papers highlight a role for glial cells in the spread of pain hypersensitivity, the importance of amino acid availability and metabolism in hematopoiesis, the epigenetics of T cell exhaustion, and similarities between plant and animal innate immunity.
- Papers of note in Science Translational Medicine
This week’s articles describe new avenues to improve immunotherapy and treat Parkinson’s disease and a way to monitor androgen receptor status while treating prostate cancer.
Erratum
- Erratum for the Research Article: “A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia” by Z. Xiao, D. Riccardi, H. A. Velazquez, A. L. Chin, C. R. Yates, J. D. Carrick, J. C. Smith, J. Baudry, L. D. Quarles
The author affiliations now appear in the correct order.
About The Cover
Online Cover This week features a Research Article that describes two micropeptides, ALN (another-regulin) and ELN (endoregulin), that inhibit calcium reuptake by the endoplasmic reticulum in diverse cell types. The image shows the distribution of mRNA transcripts encoding ALN (left) and ELN (right) in mouse embryos. [Image: Douglas M. Anderson, Department of Molecular Biology, and John M. Shelton, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, USA]