Editors' ChoiceCellular and Molecular Signaling

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Science Signaling  06 Dec 2016:
Vol. 9, Issue 457, pp. ec289
DOI: 10.1126/scisignal.aal5151


Glial cells contribute to pain

Activation of spinal glial cells induces long-term potentiation at specific synapses that spreads widely in spinal pain-sensing pathways.

M. T. Kronschläger, R. Drdla-Schutting, M. Gassner, S. D. Honsek, H. L. Teuchmann, J. Sandkühler, Gliogenic LTP spreads widely in nociceptive pathways. Science 354, 1144–1148 (2016). [Abstract]


How to maintain hematopoietic stem cells

Hematopoietic stem cell maintenance requires the amino acid valine.

Y. Taya, Y. Ota, A. C. Wilkinson, A. Kanazawa, H. Watarai, M. Kasai, H. Nakauchi, S. Yamazaki, Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation. Science 354, 1152–1155 (2016). [Abstract]

K. Ito, R. Turcotte, J. Cui, S. E. Zimmerman, S. Pinho, T. Mizoguchi, F. Arai, J. M. Runnels, C. Alt, J. Teruya-Feldstein, J. C. Mar, R. Singh, T. Suda, C. P. Lin, P. S. Frenette, K. Ito, Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354, 1156–1160 (2016). [Abstract]

P. Sommerkamp, A. Trumpp, Metabolic cues for hematopoietic stem cells. Science 354, 1103–1104 (2016). [Abstract]

The epigenetics of exhaustion

Epigenetic profiling suggests that exhausted T cells are a distinct cell lineage.

K. E. Pauken, M. A. Sammons, P. M. Odorizzi, S. Manne, J. Godec, O. Khan, A. M. Drake, Z. Chen, D. R. Sen, M. Kurachi, R. A. Barnitz, C. Bartman, B. Bengsch, A. C. Huang, J. M. Schenkel, G. Vahedi, W. N. Haining, S. L. Berger, E. J. Wherry, Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science 354, 1160–1165 (2016). [Abstract]

D. R. Sen, J. Kaminski, R. A. Barnitz, M. Kurachi, U. Gerdemann, K. B. Yates, H.-W. Tsao, J. Godec, M. W. LaFleur, F. D. Brown, P. Tonnerre, R. T. Chung, D. C. Tully, T. M. Allen, N. Frahm, G. M. Lauer, E. J. Wherry, N. Yosef, W. N. Haining. The epigenetic landscape of T cell exhaustion. Science 354, 1165–1169 (2016). [Abstract]

S. J. Turner, B. E. Russ, Can T cells be too exhausted to fight back? Science 354, 1104–1105 (2016). [Abstract]

Shared logic in diverse immune systems

Hair-trigger pathogen detection molecules form the foundation of innate immune systems in both plants and animals.

J. D. G. Jones, R. E. Vance, J. L. Dangl, Intracellular innate immune surveillance devices in plants and animals. Science 354, aaf6395 (2016). [Abstract]

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