Research ArticleCalcium signaling

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides

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Science Signaling  06 Dec 2016:
Vol. 9, Issue 457, pp. ra119
DOI: 10.1126/scisignal.aaj1460

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Inhibiting SERCA in more tissues

Calcium triggers critical signaling events in all cell types. The membrane transporter SERCA moves calcium from the cytoplasm into the sarcoplasmic or endoplasmic reticulum to keep the basal cytoplasmic concentration of calcium low. Micropeptides that inhibit SERCA have been characterized in muscle. However, SERCA isoforms are found in all tissues, leading Anderson et al. to search for micropeptides that could perform this inhibitory function in nonmuscle tissues. They discovered two such micropeptides, endoregulin (ELN) and another-regulin (ALN) which inhibit the activity of SERCA isoforms that are abundant in nonmuscle tissues. These results raise the possibility that other membrane transporters related to SERCA could also be regulated by micropeptides.

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