Contents
20 December 2016
Vol 9, Issue 459
Vol 9, Issue 459
Contents
Research Articles
- Rac signal adaptation controls neutrophil mobilization from the bone marrow
Circulating neutrophil numbers are determined by the time course of adaptation for chemokine-activated signaling in neutrophils.
- The histone deubiquitinase OTLD1 targets euchromatin to regulate plant growth
The Arabidopsis thaliana histone deubiquitinase OTLD1 represses the transcription of growth regulators and promotes plant growth.
- Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils
By recruiting the lipid phosphatase SHIP1, Fc receptors mediate not only cis-inhibition but also trans-inhibition.
- Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells
The lipid kinase DGKζ controls T cell responsiveness by converting the first signal diacylglycerol into a second signal phosphatidic acid.
Podcast
- Science Signaling Podcast for 20 December 2016: Trans-inhibition by Fc receptors
Recruitment of the lipid phosphatase SHIP1 enables trans-inhibition by Fc receptors (Malbec et al., in 20 December 2016 issue).
Editors' Choice
- Intestinal cells purge to eliminate pathogens
Bacterial pore-forming toxins cause intestinal epithelial cells to extrude their cytoplasm.
- An alternative path for pyrin
Mutations associated with an autoimmune disorder enable cells to assemble pyrin inflammasomes independently of microtubules.
- Inflammation helps tumors evade immune detection
A little less NF-κB signaling in tumor cells may be sufficient to enable cytotoxic T cells to attack the tumor.
- Papers of note in Science
This week’s articles highlight the ability of plants to defend themselves against infection by depriving invading bacteria of sugars, protein engineering to control the activation of signaling components, and mechanisms of antibiotic resistance.
- Papers of note in Science Translational Medicine
This week’s articles report a combination therapy for some breast cancer patients and identify a bacteria-mediated posttranslational mechanism of autoimmune disease.
- Serine ubiquitylation
A bacterial effector protein ubiquitylates host proteins through a mechanism that is independent of and blocks the host ubiquitylation machinery.
- A stiff path to aggressiveness
Whether a glioblastoma-associated IDH1 mutant can prevent the hypoxic induction of HIF1α depends on the stiffness of the extracellular matrix.
About The Cover
Online Cover This week features a Research Article that explores the role of diacylglycerol kinase ζ in organizing the immune synapse. The authors developed a biosensor to reveal the formation of a diacylglycerol gradient during this dynamic process. The image shows a time-lapse series of the biosensor's distribution as a Jurkat T cell interacts with a Raji B cell. [Image: Elena Andrada, CNB-CSIC, Madrid, Spain]