CANCER
Sneak attack on breast cancer’s defense
Inhibitors of BCL-XL, combined with inhibition of the mTOR/4E-BP axis, drive regressions of PIK3CA mutant breast tumors.
G. R. Anderson, S. E.Wardell, M. Cakir, L. Crawford, J. C. Leeds, D. P. Nussbaum, P. S. Shankar, R. S. Soderquist, E. M. Stein, J. P. Tingley, P. S. Winter, E. K. Zieser-Misenheimer, H. M. Alley, A. Yllanes, V. Haney, K. L. Blackwell, S. J. McCall, D. P. McDonnell, K. C. Wood, PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. Sci. Transl. Med. 8, 369ra175 (2016). [Abstract]
AUTOIMMUNITY
A joint effect of bacteria and genetics
Aggregatibacter actinomycetemcomitans generates citrullinated autoantigens involved in rheumatoid arthritis through its pore-forming toxin leukotoxin A.
M. F. Konig, L. Abusleme, J. Reinholdt, R. J. Palmer, R. P. Teles, K. Sampson, A. Rosen, P. A. Nigrovic, J. Sokolove, J. T. Giles, N. M. Moutsopoulos, F. Andrade, Aggregatibacter actinomycetemcomitans–induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci. Transl. Med. 8, 369ra176 (2016). [Abstract]
