Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases

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Science Signaling  08 Jan 2013:
DOI: 10.1126/scisignal.2003898


When considering the hierarchical organization of pathological signaling cascades in immunological disorders of the brain, certain cytokines might be considered pinnacles of pathophysiological importance, with their presence determining the appearance or the course of a particular disease. Interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor (TNF) are critical for the pathogenesis of inflammation in specific brain disorders. Targeting these cytokines or their receptors can alter the course of several neurological diseases, but the effects may be beneficial or harmful.

Full article available 15 January 2013, Vol. 6, Issue 258, pe3

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