Supplementary Materials
Supplementary Materials for:
Citation: N. Patsoukis, J. Brown, V. Petkova, F. Liu, L. Li, V. A. Boussiotis, Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation. Sci. Signal. 5, ra46 (2012).
Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation
Nikolaos Patsoukis, Julia Brown, Victoria Petkova, Fang Liu, Lequn Li, Vassiliki A. Boussiotis*
*To whom correspondence should be addressed. E-mail: vboussio{at}bidmc.harvard.edu
This PDF file includes:
- Fig. S1. Effects of PD-1 signaling on cell cycle progression.
- Fig. S2. PD-1 inhibits the kinase activity of Cdk2.
- Fig. S3. Neutralization of TGF-β does not reverse the effect of PD-1 signaling on the transcriptional activation of Smad3 or the antiproliferative function of PD-1.
- Fig. S4. PD-1 signaling inhibits activation of Akt and phosphorylation of GSK-3.
Technical Details
Format: Adobe Acrobat PDF
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Citation: N. Patsoukis, J. Brown, V. Petkova, F. Liu, L. Li, V. A. Boussiotis, Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation. Sci. Signal. 5, ra46 (2012).
