Supplementary Materials for:

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

Shingo Mutoh, Mack Sobhany, Rick Moore, Lalith Perera, Lee Pedersen, Tatsuya Sueyoshi, Masahiko Negishi*

*Corresponding author. E-mail: negishi{at}niehs.nih.gov

This PDF file includes:

• Fig. S1. Semiquantification of immunoreactive bands.
• Fig. S2. Yeast two-hybrid screening.
• Fig. S3. The RACK1 and PP2Ac interaction site on CAR.
• Fig. S4. EGF induces phosphorylation of RACK1 at Tyr⁵².
• Fig. S5. PTP1B dephosphorylates RACK1 at Tyr⁵².
• Fig. S6. Phenobarbital represses EGF-induced EGFR activation.
• Table S1. Binding energies of phenobarbital to the putative active EGFR receptor.
• Table S2. Binding energies of phenobarbital to the putative inactive EGFR receptor.

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Citation: S. Mutoh, M. Sobhany, R. Moore, L. Perera, L. Pedersen, T. Sueyoshi, M. Negishi, Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling. Sci. Signal. 6, ra31 (2013).

© 2013 American Association for the Advancement of Science