Supplementary Materials

Supplementary Materials for:

Elucidating Human Phosphatase-Substrate Networks

Xun Li, Matthias Wilmanns, Janet Thornton, Maja Köhn*

*Corresponding author. E-mail:

This PDF file includes:

  • Fig. S1. Human phosphatase-substrate network.
  • Legends for tables S1 to S16

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Technical Details

Format: Adobe Acrobat PDF

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Two hundred twenty-three enzymatically active human phosphatases.
  • Table S2 (Microsoft Excel format). Human phosphatase domains and enzyme classes of human proteins and human active phosphatases containing these domains.
  • Table S3 (Microsoft Excel format). Human phosphatases and their protein and nonprotein substrates.
  • Table S4 (Microsoft Excel format). Substrate hubs in the human phosphatase-substrate network and phosphatases targeting these substrate hubs (grouped by substrate cluster).
  • Table S5 (Microsoft Excel format). Colocalization and coexpression analysis of phosphatases and substrates.
  • Table S6 (Microsoft Excel format). Detailed distributions of substrates in different localizations for a subset of phosphatases.
  • Table S7 (Microsoft Excel format). Sequence logos and derived amino acid and property patterns of target dephosphorylation sites for 35 human active phosphatases.
  • Table S8 (Microsoft Excel format). CATH domain–containing dephosphorylation sites for substrates of phosphatases with 15 or more protein substrates.
  • Table S9 (Microsoft Excel format). CATH domain composition for substrates of phosphatases with 15 or more protein substrates.
  • Table S10 (Microsoft Excel format). Human proteins that contain the CATH domain combination
  • Table S11. Comparison of CATH domains that are part of protein substrates recognized by PP1 and PP2A.
  • Table S12. Protein substrates of human kinases.
  • Table S13. Phosphatases and kinases and their shared substrates and (de)phosphorylation sites.
  • Table S14. Comparison of number of phosphatases and kinases targeting specific substrates.
  • Table S15. Statistics of substrate sharing between kinases and phosphatases.
  • Table S16. KEGG pathways and NCI Nature PID (Pathway Interaction Database) pathways involving human active phosphatases and their substrates.

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Citation: X. Li, M. Wilmanns, J. Thornton, M. Köhn, Elucidating Human Phosphatase-Substrate Networks. Sci. Signal. 6, rs10 (2013).

© 2013 American Association for the Advancement of Science